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KMID : 0939920190510041568
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대한암학회지
2019 Volume.51 No. 4 p.1568 ~ p.1577
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Inter-observer Reproducibility in the Pathologic Diagnosis of Gastric Intraepithelial Neoplasia and Early Carcinoma in Endoscopic Submucosal Dissection Specimens: A Multi-center Study
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Kim Joon-Mee
Sohn Jin-Hee
Cho Mee-Yon
Kim Woo-Ho
Chang Hee-Kyung
Jung Eun-Sun
Kook Myeong-Cherl
Jin So-Young
Chae Yang-Seok
Park Young-Soo
Kang Mi-Seon
Kim Hyun-Ki
Lee Jae-Hyuk
Park Do-Youn
Kim Kyoung-Mee
Kim Ho-Guen
Suh Young-Ju
Seol Sang-Yong
Jung Hwoon-Yong
Kim Deuck?Hwa
Lee Na-Rae
Park Seung-Hee
You Ji-Hye
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Abstract
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Purpose: The diagnostic criteria of gastric intraepithelial neoplasia (IEN) are controversial across the world. We investigated how many discrepancies occur in the pathologic diagnosis of IEN and early gastric carcinoma in endoscopic submucosal dissection (ESD) specimens, and evaluated the reasons of the discordance.
Materials and Methods: We retrospectively reviewed 1,202 ESD specimens that were originally diagnosed as gastric IEN and early carcinoma at 12 institutions.
Results: The final consensus diagnosis of carcinoma were 756 cases, which were originally 692 carcinomas (91.5%), 43 high-grade dysplasias (5.7%), 20 low-grade dysplasias (2.6%), and 1 others (0.1%), respectively. High- and low-grade dysplasia were finally made in 63 and 342 cases, respectively. The diagnostic concordance with the consensus diagnosis was the highest for carcinoma (91.5%), followed by low-grade dysplasia (86.3%), others (63.4%) and high-grade dysplasia (50.8%). The general kappa value was 0.83, indicating excellent concordance. The kappa values of individual institutions ranged from 0.74 to 1 and correlated with the proportion of carcinoma cases. The cases revised to a final diagnosis of carcinoma exhibited both architectural abnormalities and cytologic atypia. The main differential points between low- and high-grade dysplasias were the glandular distribution and glandular shape. Additional features such as the glandular axis, surface maturation, nuclear stratification and nuclear polarity were also important.
Conclusion: The overall concordance of the diagnosis of gastric IEN and early carcinoma in ESD specimens was excellent. It correlated with the proportion of carcinoma cases, demonstrating that the diagnostic criteria for carcinoma are more reproducible than those for dysplasia.
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KEYWORD
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Intraepithelial neoplasia, Stomach neoplasms, Endoscopic mucosal resection, Discrepancy, Reproducibility
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